Recent technological developments in wireless communications and mobile networks, broadband networks, pervasive computing, and distributed computing have led to a wide variety of new challenging problems. These include the provisioning of Quality of Service (QoS), survivability, resilience and scalability in a wide range of emerging applications and services over large-scale wired and wireless networks.The Sixth International Conference on Heterogeneous Networking for Quality, Reliability, Security and Robustness (QShine 2009) will focus on the research challenges associated to the design and implementation of large-scale wired and wireless networks and distributed systems. The aim of this conference is to bring together research and practitioners to present and share the latest results in the areas of performance, configuration, cross-layer approaches, scalability, resilience and survivability of large scale heterogeneous networks and distributed systems. Following the tradition of the previous QShine meetings, QShine 2009 will feature prominent invited speakers as well as papers by top researchers in the field.