Over the past seven years Next-Generation Sequencing has fundamentally altered genomics research.  Falling costs have catalysed large knowledge-gaining experiments that were financially unjustifiable or impossible five years ago.  These include metagenomic research into patient variablility, sequencing of model and pathogenic species and ELT compound library screening techniques. Storage, analysis and interpretation of the data however, remain major and consistent obstacles.  Focusing on these challenges, SMi’s Next-Generation Sequencing conference features a problem-solving approach to accelerate your research, product and clinical development. Whether clarifying the molecular basis of disease, developing new antimicrobials or developing better protein therapeutics, join our expert faculty this September to:  Generate longer nucleic acid and oligonucleotide sequences of higher qualityIncrease consensus accuracy and genome coverageMaximise the alignment and assembly of NGS reads with reference sequencesEnhance signal-to-noise measurements in real-time sequencingUtilise exomics to elucidate gene families implicated in disease or pharmacogenetic effectsImprove mapping in repetitive regions when resequencingPLUS TWO INTERACTIVE HALF-DAY POST-CONFERENCE WORKSHOPSWednesday 19th September 2012, Copthorne Tara Hotel, LondonA: RNA-sequencing – analytical challenges and data interpretationWorkshop Leader: John Marioni, Group Leader, European Bioinformatics Institute8.30am - 12.40pm B: Challenges in bacterial genome sequence data interpretationWorkshop Leader: Lori Snyder, Reader in Biotechnology, Kingston University1.30pm - 5.40pmAlternatively contact Lewis Garfield on tel: +44 (0) 20 7827 6186 **Book by 31st May 2012 and Save £300**