Ensuring that factories are cleaned and disinfected effectively is a fundamental pre-requisite in food and drink production. However, a number of issues are coming to the fore, such as BRC 6 validation of prerequisites, environmental monitoring, and cross contamination control. There has also been much media interest regarding disinfectant resistance.This seminar will look at several aspects of cleaning validation, including allergen control, as well as examples of whole room disinfection, and will attempt to untangle the myths from the facts surrounding disinfectant resistance.