Overview: This webinar will begin with a discussion of the physical properties of materials that are commonly used to formulate freeze-dried products, and the impact that these materials can have on how products freeze-dry (in regards to the physical and chemical integrity). Understanding if a crystalline, amorphous, mixed, and or metastable system is present in our products, is critical in developing a sound, stable formulation that can easily be freeze-dried. Areas Covered in the Session:Crystalline vs. amorphous vs. mixed systemsEutectic melting, glass transition, and collapse temperaturesPartial collapse vs. meltbackExamples of failed productsPrincipals of thermal analysisThermal analysis equipment and techniques: DSC, DTA, TEAFreeze-dry microscopy equipment and techniquesApplications of thermal analysis and freeze-dry microscopy techniques for solutions and solidsLearning Objectives:Understanding the thermal properties of a formulation (crystalline, amorphous, mixed)Understanding the critical temperatures (Tg', Te, Tc) of a formulationUnderstanding different excipients in formulations and how they affect the thermal propertiesWho Will Benefit:Quality Control ScientistsDevelopment ScientistsProduction ManagementQuality AssuranceJeff Schwegman, Ph.D. is currently the founder and chief executive officer of AB BioTechnologies where he develops formulations, lyophilization cycles, determines residual moisture by Karl Fischer, and provides thermal characterization studies including freeze-dry microscopy and DSC. GlobalCompliancePanel Phone: 800-447-9407Fax: 302-288-6884