We use cookies to personalise content and ads, to provide social media features and to analyse our traffic. We may also share information about your use of our site with our social media, advertising and analytics partners. Read more about our Privacy Policy.

I got it!

EMBL Course: Attacking Open Chromatin with ATAC Sequencing

EMBL Course

ATAC-Seq stands for Assay of Transposase Accessible Chromatin and is, despite its recent invention, already a widespread method to profile open chromatin on a genome-scale. The goal of this course is to teach the entire workflow of an ATAC-Seq experiment including library preparation, sequencing, data processing, and downstream analysis by addressing a real biological question that will be answered at the end of the course.

We will start with the experimental ATAC-Seq protocol, highlighting the critical steps, potential pitfalls, and the most up-to-date tweaks to improve the quality of the results. After sequencing the samples we will go through the basic quality control and preprocessing steps using multiple analysis tools for next generation sequencing data. Finally, we will perform different types of analysis on the processed data, including visualisation, differential peak calling, and differential transcription factor activity profiling to come to a biological conclusion. In addition we will discuss recent advancements in technology development and algorithms for analysis and give an outlook on future perspectives and applications.


10 Sep 2018 @ 12:00 am

14 Sep 2018 @ 12:01 am

Duration: 4 days




69117 Heidelberg


Organised by

European Molecular Biology Laboratory

Recent Publications in Biology

Recent Videos in Biology

Recent News in Biology

Research on #sepsis is funded by ERC in a bottom-up way, highlights @EUScienceInnov’s Cornelius Schmaltz, informing… https://t.co/U5mM1QI5kk

@ERC_Research - 18 Mar 2019 20:21

As the European Innovation Council #EIC launches the second phase of its pilot, we look at why Europe needs an inno… https://t.co/CJLjIQLleb

@HorizonMagEU - 18 Mar 2019 18:06

Sepsis - one of the most preventable causes of death and disability in Europe. Awareness and research needed. Luis… https://t.co/nPWty5H5wM

@ERC_Research - 18 Mar 2019 17:51

Recent Speakers in Biology