A balanced immune response is maintained by a network of regulatory cells including T cells, B cells and iNKT cells. How these cells respond to their environment in order to dampen down inflammation and what goes wrong in autoimmunity, will be the focus of this meeting. Novel insights into positive and negative feedback mechanisms that help balance the immune environment will be discussed. It is only by understanding how immune regulation is maintained in health and what goes wrong during autoimmunity that new targets for therapy can be identified. We welcome abstract submission for this meeting: selected abstracts will be selected for short oral presentation