Systems biology largely focuses on the study of the organization and operation of the biological systems at various levels: molecular genetic entities, cells, tissues, organs and organisms on the basis of information encoded in their genomes.Systems biology strongly depends on high-performance experimental technologies: * sequencing of genomic DNA, analysis of its between-population and evolutionary variation; * study of the expression of genes and gene complexes using biochips-based modalities; * structural and functional analysis of proteins and metabolites using mass spectrometric methods; * study of the structural and functional organization of biological objects (macromolecules, chromosomes, cells, tissues, organs, organisms) using modern microscopic methods; * construction of artificial molecular genetic systems using genetic engineering techniques.(source: www.bionet.nsc.ru)